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Updated: Oct 16, 2026

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Controlling stereoselectivity with the aid of a reagent-directing group: hydroformylation, cuprate addition, and
1Organisch-Chemisches Institut der Ruprecht-Karls-Universitat, Heidelberg, Germany. bernhard.breit@urz.uni-heidelberg.de
Abstract:
The specific introduction of an appropriately designed reagent-directing group into an organic substrate allows the more efficient use of substrate direction to allow high levels of acyclic stereocontrol in both rhodium-catalyzed hydroformylation and cuprate addition to enoates. This provides access to major building blocks of the polyketide class of natural products. Incorporation of these directed reactions into sequential transformations holds promise for new particularly efficient synthetic methods.
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