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Updated: Oct 16, 2026

Isolation of Human Umbilical Vein Endothelial Cells (HUVEC)
Published on: April 28, 2007
Fluvastatin increases prostacyclin and decreases endothelin production by human umbilical vein endothelial cells
H Seeger1, A O Mueck, T H Lippert
1Department of Obstetrics and Gynecology, University of Tübingen, Germany.
Abstract:
Fluvastatin, an agent of a class of lipid-lowering drugs, the "statins", significantly enhanced prostacyclin synthesis at the concentrations of 0.1 microM and 1 microM and significantly reduced endothelin production at the concentrations 0.01, 0.1 and 1 microM in cell cultures of human umbilical endothelial veins. Since prostacyclin is a vasodilator and endothelin a vasoconstrictor, fluvastatin may have a significant effect on hemodynamics by favoring the balance towards vasodilation. This mechanism may contribute to the prevention of cardiovascular diseases.
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