Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circadian rhythms, aging and memory.

E A Antoniadis1, C H Ko, M R Ralph

  • 1Departments of Psychology and Zoology, University of Toronto, 100 St George Street, Ont., M5S 3G3, Toronto, Canada. elena@psych.utoronto.ca

Behavioural Brain Research
|June 7, 2000
PubMed
Summary

Disrupted circadian rhythms in aging hamsters impair memory. Fragmented rhythms, not just aging, caused this cognitive decline, suggesting a direct link between rhythm disruption and memory loss.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seed dormancy and germination of three Corydalis species, disjunct relict species in East Asia.

Plant biology (Stuttgart, Germany)·2026
Same author

Effect of forefoot strike and toe-out running on knee contact forces: a musculoskeletal modelling-based study.

Sports biomechanics·2025
Same author

Chronic gut inflammation impairs contextual control of fear.

Scientific reports·2022
Same author

Differentiating episodic ataxia type 2 from migraine: a case report.

Hong Kong medical journal = Xianggang yi xue za zhi·2020
Same author

Antioxidative effect of Gastrodiae Rhizoma-containing herbal formula in PC12 cell model: abridged secondary publication.

Hong Kong medical journal = Xianggang yi xue za zhi·2020
Same author

Dentate Update: Imaging Features of Entities That Affect the Dentate Nucleus.

AJNR. American journal of neuroradiology·2017

Area of Science:

  • Neuroscience
  • Chronobiology
  • Gerontology

Background:

  • Circadian rhythm disruption is linked to cognitive impairment in humans and animals.
  • Aging is associated with both cognitive decline and fragmented behavioral rhythms.
  • A direct causal link between age-related rhythm disruption and cognitive impairment remains unclear.

Purpose of the Study:

  • To investigate the causal relationship between age-related circadian rhythm fragmentation and cognitive decline.
  • To examine the impact of rhythm disruption on memory performance in elderly hamsters.

Main Methods:

  • Utilized a conditioned place preference task to assess contextual learning and memory in young and aged hamsters.
  • Compared performance between aged hamsters with consolidated versus fragmented locomotor rhythms.

Related Experiment Videos

  • Correlated memory preference with activity amplitude.

    • Main Results:

    • Young hamsters and aged hamsters with consolidated rhythms showed significant place preference.
    • Aged hamsters with fragmented rhythms did not develop a significant preference.
    • Preference was positively correlated with activity amplitude.

    Conclusions:

    • Age-related fragmentation of circadian rhythms contributes to age-related memory decline.
    • Rhythm disruption, independent of age alone, can impair cognitive function.
    • Maintaining consolidated circadian rhythms may be crucial for preserving memory in aging populations.