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Related Experiment Videos

Melanocortins and feeding behavior.

A V Vergoni1, H B Schiöth, A Bertolini

  • 1Department of Biomedical Sciences, University of Modena, Italy.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|June 7, 2000
PubMed
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Melanocortins centrally control appetite by inhibiting feeding behavior via the MC4 receptor. Blocking this receptor reduces food intake and stress-induced anorexia, highlighting its role in appetite regulation.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Appetite Regulation

Background:

  • Melanocortin peptides (ACTH/MSH) have central effects, including appetite control.
  • Early research demonstrated melanocortin-induced reduction in food intake in rodents.
  • The MC4 receptor is crucial for mediating melanocortin effects on feeding behavior.

Purpose of the Study:

  • To investigate the role of melanocortins and the MC4 receptor in central appetite control.
  • To evaluate the effects of MC4 receptor agonists and antagonists on feeding behavior and body weight.
  • To determine if MC4 receptor blockade influences stress-induced anorexia.

Main Methods:

  • Injections of ACTH-(1-24) into brain ventricles and hypothalamus of rats.
  • Studies using genetically modified mice with disrupted MC4 receptors.

Related Experiment Videos

  • Administration of MC4 receptor agonists and selective antagonists in rodents.
  • Assessment of food intake, body weight, and stress-induced anorexia.

    • Main Results:

    • Central melanocortin administration significantly reduced food intake in rats, mice, and rabbits.
    • MC4 receptor disruption led to obesity in mice.
    • MC4 receptor agonists decreased food intake and body weight; antagonists had the opposite effect.
    • MC4 receptor antagonists partially reversed immobilization stress-induced anorexia with sustained effects.

    Conclusions:

    • Melanocortins play a tonic inhibitory role in feeding behavior through central MC4 receptors.
    • MC4 receptor blockade is effective in reducing food intake and stress-induced anorexia.
    • CRF-induced anorexia and grooming are independent of central melanocortin pathways.