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Related Experiment Videos

[Marginal zone lymphomas: extranodal MALT type, nodal and splenic].

F E Dallenbach1, S E Coupland, H Stein

  • 1Institut für Pathologie des Universitätsklinikums Benjamin Franklin, Freie Universität Berlin.

Der Pathologe
|June 7, 2000
PubMed
Summary

Marginal zone B-cell lymphomas (MCL) are distinct entities, with extranodal MCL of Mucosa-Associated Lymphoid Tissue (MALT) type showing a good prognosis. Further research is needed for nodal and splenic MCL prognosis.

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Area of Science:

  • Hematology
  • Oncology
  • Immunopathology

Context:

  • Marginal zone B-cell lymphomas (MCL) encompass extranodal, nodal, and splenic origins, sharing a similar growth pattern.
  • The "MALT concept" was crucial in identifying MCL as a distinct entity, particularly for gastric and intestinal mucosa infiltrates.
  • Immunohistological and molecular studies confirmed the neoplastic nature of extranodal infiltrates and distinguished marginal zone from mantle zone cells.

Purpose:

  • To review the classification and diagnostic features of marginal zone B-cell lymphomas.
  • To highlight the diagnostic significance of the MALT concept and lymphoepithelial lesions in extranodal MCL.
  • To discuss the clinical prognosis of extranodal MCL and identify areas for future research.

Summary:

  • Extranodal MCL of MALT type, found in various organs with gastric mucosa being most common, exhibit characteristic lymphoepithelial lesions.

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  • Small cell extranodal MCL demonstrate a favorable prognosis with treatment-induced regression.
  • Further studies are required to fully evaluate prognostic aspects of nodal and splenic MCL and compare them with other B-cell lymphomas.

    • Impact:

    • Established MCL as distinct lymphoma entities through the MALT concept and advanced classification systems (REAL, WHO).
    • Identified key diagnostic features like lymphoepithelial lesions for extranodal MCL.
    • Provided insights into the prognosis of extranodal MCL, emphasizing the need for further research in nodal and splenic subtypes.