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Congenital hypothyroidism control programs. A cost-benefit analysis

P M Layde, S D Von Allmen, G P Oakley

    JAMA
    |May 25, 1979
    PubMed

    Insights

    Screening neonates for congenital hypothyroidism (CH) is cost-effective. Early detection and treatment of CH prevent mental retardation, offering significant economic benefits that outweigh program costs.

    Area of Science:

    • Public Health
    • Pediatrics
    • Endocrinology

    Background:

    • Congenital hypothyroidism (CH) is a preventable cause of mental retardation.
    • Early screening and intervention are crucial for managing CH.
    • Public health agencies are evaluating comprehensive CH screening programs.

    Purpose of the Study:

    • To assess the cost-effectiveness of newborn screening for congenital hypothyroidism (CH).
    • To determine the economic benefits of early CH detection and treatment.

    Main Methods:

    • Analysis of costs associated with CH screening, including specimen collection, laboratory analysis, and follow-up.
    • Calculation of present value for treatment costs and economic benefits (averted institutionalization, special education, increased productivity).

    Main Results:

    • The estimated cost to detect and treat a single case of CH is $11,800.
    • Economic benefits, including averted costs and increased productivity, are estimated at $105,000 per case.
    • The cost-benefit ratio for CH screening and treatment is approximately 1:8.9.

    Conclusions:

    • Newborn screening for congenital hypothyroidism is highly cost-effective.
    • Implementing CH screening programs yields substantial economic benefits, significantly outweighing the costs.
    • Early detection and treatment of CH are vital for preventing mental retardation and improving long-term outcomes.

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