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Nosocomial enterococcal infections in children.
N Singh-Naz1, A Rakowsky, E Cantwell
1Department of Infectious Diseases, Children's National Medical Center, George Washington University School of Medicine, Washington DC 20010, USA.
The Journal of Infection
|June 7, 2000
Summary
Central lines, gastrointestinal issues, and multiple antibiotics increase nosocomial enterococcal infections in children. Limiting antibiotic use in high-risk patients may help control these infections.
Area of Science:
- Pediatric Infectious Diseases
- Hospital-Acquired Infections
- Antimicrobial Resistance
Background:
- Nosocomial enterococcal infections pose a significant threat in pediatric healthcare settings.
- Understanding risk factors is crucial for effective prevention strategies.
Purpose of the Study:
- To identify key factors associated with an increased risk of nosocomial enterococcal infection in pediatric patients.
- To inform targeted interventions for infection control.
Main Methods:
- A matched case-control study was conducted involving 101 pediatric cases and 101 controls.
- Data were collected via systematic review of medical records.
- Microbiology methods included isolation, identification, and antimicrobial susceptibility testing.
Main Results:
- Central line placement was identified as a significant risk factor.
- Gastrointestinal tract pathology was associated with increased infection risk.
- Administration of multiple antimicrobial agents was a key determinant.
Conclusions:
- Limiting the number of antimicrobial agents administered to hospitalized high-risk children may help control nosocomial enterococcal infections.
- Findings are particularly relevant given rising antimicrobial resistance rates.
- Targeted interventions focusing on central line care and judicious antibiotic use are recommended.