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Recurrent venous thrombosis in a patient with chronic lymphocytic leukemia and acquired protein S deficiency
P Miljić1, N Milosević-Jovicić, P Antunović
1Institute of Haematology, University Clinical Center, Belgrade, Yugoslavia.
Abstract:
A patient with chronic lymphocytic leukemia and an undetectable plasma level of protein S (PS), associated with recurrent venous thrombosis, is described. The laboratory investigation revealed the concomitant presence of an inhibitor directed to PS and a monoclonal protein in the patient's plasma. After treatment with prednisone and cyclophosphamide both the inhibitor to PS and the monoclonal component disappeared.