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Host cyclooxygenase-2 modulates carcinoma growth

C S Williams1, M Tsujii, J Reese

  • 1Department of Medicine, The Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2279, USA.

The Journal of Clinical Investigation
|June 7, 2000
PubMed
Summary

Cyclooxygenase-2 (COX-2) promotes tumor growth by enhancing vascularization. Inhibiting COX-2 in mice significantly reduced tumor size and blood vessel formation, highlighting its role in cancer progression.

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