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Microbiological high throughput screening: an opportunity for the lead discovery process
M H Beydon1, A Fournier, L Drugeault
1HTS, Aventis Pharma, Centre de Recherche de Vitry-Alfortville, Vitry sur Seine, France. jerome.becquart@aventis.com
Journal of Biomolecular Screening
|June 7, 2000
Summary
Rhône-Poulenc Rorer developed a robotic platform for microbial High-Throughput Screening (HTS). This system enhances lead discovery through flexible, cost-effective solid-phase microbial screening.
Area of Science:
- Microbiology
- Drug Discovery
- Biotechnology
Background:
- High-Throughput Screening (HTS) is crucial for identifying novel drug leads.
- Microbial screening offers unique advantages for certain discovery processes.
- Integrating HTS into lead discovery workflows requires specialized platforms.
Purpose of the Study:
- To describe the development and implementation of a dedicated robotic platform for microbial HTS.
- To showcase innovative solutions for achieving high throughput and flexibility in microbial screening.
- To explore the potential of solid-phase microbial screening in drug discovery.
Main Methods:
- Development of a robotic platform named Turbo for microbial HTS.
- Implementation of innovative engineering solutions for enhanced throughput and flexibility.
- Application of solid-phase microbial screening techniques.
Main Results:
- Successful integration of microbial HTS into lead discovery processes.
- Demonstration of high throughput and flexibility with the Turbo platform.
- Identification of cost-effective and easily implementable screening methods.
Conclusions:
- The developed robotic platform significantly advances microbial HTS capabilities.
- Solid-phase microbial screening presents a promising avenue for lead discovery.
- Microbial HTS offers distinct advantages over biochemical and cell-based assays in specific contexts.