Related Experiment Videos
Synthesis of trans-2-(1-aryl-1-methylethyl)cyclohexylamines
W Y Lee1, J M Salvador, K Bodige
1Department of Chemistry, University of Texas at El Paso 79968, USA.
Organic Letters
|April 18, 2000
Abstract:
As a first example of opening a secondary aziridine with a tertiary carbanion, the title amines (3a-c, aryl = phenyl, 4-tert-butylphenyl,2-naphthyl) were synthesized by opening N-(diphenylphosphinoyl)-7-azabicyclo[4.1.0]heptane, aziridine 1, with the corresponding alpha-potassium isopropylarenes, followed by a hydrolysis of the resulting phosphinamides 2a-c.