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Related Experiment Videos

Skeletal muscle response to tenotomy.

A A Jamali1, P Afshar, R A Abrams

  • 1Department of Orthopedics, University of California, San Diego 92093-9151, USA.

Muscle & Nerve
|June 8, 2000
PubMed
Summary

Tenotomy, the surgical cutting of a tendon, causes molecular, architectural, and functional changes in skeletal muscle. Understanding these responses is crucial for treating tendon injuries and iatrogenic damage.

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Area of Science:

  • Skeletal muscle physiology
  • Biomedical engineering
  • Orthopedic research

Background:

  • Tenotomy, whether traumatic or iatrogenic, is a frequent clinical occurrence.
  • Skeletal muscle exhibits complex responses to tendon disruption.
  • Previous research has not comprehensively detailed these multi-faceted changes.

Purpose of the Study:

  • To review and categorize the molecular, architectural, and functional responses of skeletal muscle to tenotomy.
  • To provide a consolidated understanding of muscle alterations following tendon injury.
  • To highlight the clinical relevance of these changes in pathological states.

Main Methods:

  • Literature review of studies investigating skeletal muscle response to tenotomy.
  • Categorization of observed changes into molecular, architectural, and functional domains.
  • Synthesis of findings related to myofiber structure, protein expression, and muscle function.

Main Results:

  • Architectural changes include myofiber disorganization, necrosis, fibrosis, and altered sarcomere number.
  • Molecular alterations involve transient changes in myosin heavy chain composition and neural cell adhesion molecule (NCAM) expression.
  • Functional deficits manifest as decreased maximum tetanic and twitch tension in tenotomized muscle.

Conclusions:

  • Tenotomy induces significant and diverse alterations in skeletal muscle structure and function.
  • These changes impact muscle's molecular makeup, physical organization, and force-generating capacity.
  • Understanding these responses is vital for managing clinical conditions resulting from tendon rupture and iatrogenic tenotomy.

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