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Immunonutrition - fact or fad.

H Schneider1, S W Atkinson

  • 1Departments of Surgery and Intensive Care, Guy's Hospital, London SE1 9RT, UK.

The Journal of Nutrition, Health & Aging
|June 8, 2000
PubMed
Summary
This summary is machine-generated.

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Nutritional supplements, including arginine, glutamine, nucleotides, and omega-3 fatty acids, can enhance immune function. Immunonutrition, when administered adequately, reduces complications and improves outcomes in patients with multiple organ failure.

Area of Science:

  • Nutrition Science
  • Immunology
  • Critical Care Medicine

Background:

  • Dietary modifications for health benefits are well-established.
  • Emerging research highlights the impact of nutritional supplements on immune function.
  • Specific supplements like arginine, glutamine, nucleotides, and omega-3 fatty acids are of interest.

Purpose of the Study:

  • To review the evidence on the effects of specific nutritional supplements on immune function.
  • To analyze clinical trials focusing on patients with multiple organ failure.
  • To assess the role of immunonutrition in patient recovery.

Main Methods:

  • Literature review of existing studies on nutritional supplements and immune function.
  • Focus on clinical trials involving patients in multiple organ failure.

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  • Examination of data on septic complications and surrogate outcome measures.

    • Main Results:

    • Evidence suggests that immunonutrition can positively influence immune function.
    • Adequate pre- and post-operative absorption of supplements is crucial.
    • Reductions in septic complications were observed.
    • Improvements in length of stay and reduced need for mechanical ventilation were noted.

    Conclusions:

    • Immunonutrition shows promise in managing patients with multiple organ failure.
    • Timely and adequate administration of supplements is key to efficacy.
    • Further research may solidify the role of immunonutrition in critical care settings.