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Updated: Aug 7, 2026
Modeling and Imaging 3-Dimensional Collective Cell Invasion
Published on: December 7, 2011
Self-organization and competition in the immune response to cancer invasion: a phase-orientated computational model
S A Oprişan1, A Ardelean, P T Frangopol
1Al.I. Cuza University, Department of Theoretical Physics, Iaşi, Romania. soprisan@uno.edu
Motivation:
Recent studies indicate that fractal dimensions can uncover aspects of cellular dynamics prior to pathological manifestation. In this respect we are interested in building a computational model of oncogenesis able to generate patterns with the same fractal dimension spectrum as the in vivo tumor.
Results:
A new theoretical model incorporating a systemic view of oncogenesis in a computational model was proposed. The tumor growth is viewed as competition for resources between the two self-organizing subsystems: the neoplastic and the immune. Numerical simulations revealed that tumor escape can be uncovered in some earlier stage of the immune-system-tumor interaction using multifractal measures. The described computational model is able to simulate also the case of immune, surgical, chemical and radiotherapeutical treatment, as well as their effects.
Availability:
T The software used is available on request from the authors.
Contact:
Sorinel Oprisan, University of New Orleans, Department of Psychology, Ne w Orleans, LA 70148, USA. soprisan@uno.edu
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