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Anti-AIDS agents part 41: synthesis and anti-HIV activity of 3',4'-di-o-(-)-camphanoyl-(+)-cis-khellactone (DCK)

Z Y Yang¹, Y Xia, P Xia

¹Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599, USA.

Bioorganic & Medicinal Chemistry Letters

|June 8, 2000

Abstract:

DCK lactam analogues were synthesized and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. 4-Methyl-DCK lactam (11a) exhibited potent anti-HIV activity with EC50 and therapeutic index values of 0.00024 microM and 119,333, respectively.

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