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Structure-activity relationship studies of flavopiridol analogues
K K Murthi1, M Dubay, C McClure
1Department of Medicinal Chemistry, Mitotix Inc., Cambridge, MA 02139, USA. murthi@mitotix.com
Bioorganic & Medicinal Chemistry Letters
|June 8, 2000
Abstract:
Cyclin dependent kinases (CDKs) along with the complementary cyclins form key regulatory checkpoint controls on the cell cycle. Flavopiridol is a synthetic flavone that shows potent and selective cyclin-dependent kinase inhibitory activity. In this paper, we report modifications of the 3-hydroxy-1-methylpiperidinyl (D ring) of flavopiridol and their effect on CDK inhibitory activity.