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Antimycobacterial activity of ionic fullerene derivatives
S Bosi1, T Da Ros, S Castellano
1Dipartimento di Scienze Farmaceutiche, Università di Trieste, Italy.
Bioorganic & Medicinal Chemistry Letters
|June 8, 2000
Abstract:
Positively charged fullerene derivatives, moderately soluble in water:DMSO 9:1, have been tested using three strains of Mycobacterium spp. Some compounds inhibit the growth of Mycobacterium tuberculosis, a human clinical isolate, particularly virulent and resistant, at doses as low as 5 microg/mL.