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Anomalous temperature dependence of peptide films at air-water interface
1Bioorganic Laboratory, Central Leather Research Institute, Adyar, Chennai, India.
Bioorganic & Medicinal Chemistry Letters
|June 8, 2000
Abstract:
The tetrapeptide derivative Tyr-Gly-Phe-Ala-OBz (1) forms monolayers as confirmed by compressibility studies carried out at various temperatures. Peptide 1 monolayer exhibits an anomalous structural transition at 40 degrees C as evidenced by pi-A isotherms recorded at different temperatures. The structural transition is also observed in aqueous solution of trifluoroacetate of peptide 1 as evidenced by fluorescence and Raman scattering intensity measurements.