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First pharmacophoric hypothesis for 5-HT7 antagonism
M L López-Rodríguez1, E Porras, B Benhamú
1Departamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense, Madrid, Spain. mluzlr@eucmax.sim.ucm.es
Bioorganic & Medicinal Chemistry Letters
|June 8, 2000
Abstract:
In order to make the first contribution to the elucidation of essential structural features for 5-HT7 antagonism, a set of thirty 5-HT7 antagonists were selected from the literature. A pharmacophore model was built using Molecular Modeling studies with Catalyst program. The information contained in this model was validated with new synthesized compounds.