Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A second amplifier function for the allergy-associated Fc(epsilon)RI-beta subunit.

E Donnadieu1, M H Jouvin, J P Kinet

  • 1Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

Immunity
|June 8, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms.

Journal of molecular biology·2001
Same author

Imaging T-cell antigen recognition and comparing immunological and neuronal synapses.

Immunology·2001
Same author

Minimal requirements for IgE-mediated regulation of surface Fc epsilon RI.

Journal of immunology (Baltimore, Md. : 1950)·2001
Same author

Essential role for Gab2 in the allergic response.

Nature·2001
Same author

Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells.

American journal of respiratory and critical care medicine·2001
Same author

LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability.

Nature·2001
Same journal

Targeting cholesterol esterification sensitizes liver cancer to CD8<sup>+</sup> T cell attack by impairing metabolic and redox resilience.

Immunity·2026
Same journal

Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing.

Immunity·2026
Same journal

Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors.

Immunity·2026
Same journal

B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection.

Immunity·2026
Same journal

Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion.

Immunity·2026
Same journal

Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling.

Immunity·2026
See all related articles

The high-affinity IgE receptor (FcεRI) beta subunit amplifies allergic responses by enhancing FcεRI signaling and cell surface expression. This dual amplification in effector cells leads to significantly increased downstream allergic events.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • The gene for the high-affinity IgE receptor (FcεRI) beta subunit is a candidate for atopy.
  • Previous research demonstrated the beta subunit's role as a signaling amplifier for allergic responses.

Purpose of the Study:

  • To investigate the additional functions of the FcεRI beta subunit beyond signaling amplification.
  • To elucidate the molecular mechanisms underlying FcεRI cell surface expression.

Main Methods:

  • Investigated the association between FcεRI beta and alpha subunits.
  • Analyzed the impact of beta subunit on FcεRI trafficking and maturation.
  • Compared FcεRI density in different cell types.

Main Results:

Related Experiment Videos

  • The FcεRI beta subunit amplifies FcεRI cell surface expression through early association with the alpha subunit.
  • This association improves the trafficking and maturation of alpha and FcεRI complexes.
  • FcεRI density is significantly higher in beta+ effector cells (mast cells, basophils) compared to beta-cells (monocytes, dendritic cells).

Conclusions:

  • The FcεRI beta subunit possesses a dual amplification function: enhancing both signaling and cell surface expression of the receptor.
  • These amplification mechanisms provide a molecular basis for the differential FcεRI expression observed in various immune cells.
  • Combined effects result in a 12- to 30-fold amplification of downstream events in effector cells, contributing to atopy.