Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Single-versus multiple-dose antibiotics prophylaxis for cardiac surgery.

S J Bucknell1, M Mohajeri, J Low

  • 1Department of Cardiothoracic Surgery, Geelong Hospital, Victoria, Australia. sarahtrout@hotmail.com

The Australian and New Zealand Journal of Surgery
|June 8, 2000
PubMed
Summary

Single-dose antimicrobial prophylaxis is as effective as a 48-hour regimen for cardiac surgery patients, with a low overall infection rate. This approach is sufficient and cost-effective for preventing surgical site infections.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of concentrate crude protein concentration and replacing imported feed ingredients with locally grown cereals and faba bean on milk production and nitrogen utilization in grazing dairy cows.

Journal of dairy science·2026
Same author

Expression of interferon-stimulated genes in the endometrium, cervix and vagina on Day 15 of pregnancy in cattle.

Theriogenology·2026
Same author

Staphylococcal Toxic Shock Syndrome: The Critical Role of Early Recognition and Prompt Intervention.

Irish medical journal·2026
Same author

Shaping the Future of Respiratory Care: A Look Into the Next Decade and Strategic Recommendations by the European Forum for Research and Education in Allergy and Airways Diseases.

Chest·2026
Same author

Physiotherapy interventions for the respiratory management of people with spinal cord injury: recommendations from an Australian and New Zealand clinical practice guideline.

Spinal cord·2025
Same author

Erratum to "Incidence and timing of pregnancy loss following timed artificial insemination or timed embryo transfer with a fresh or frozen in vitro-produced embryo" (J. Dairy Sci. 108:1022-1038).

Journal of dairy science·2025

Area of Science:

  • Infectious Diseases
  • Cardiovascular Surgery
  • Pharmacology

Background:

  • Determining optimal antimicrobial prophylaxis duration for cardiac surgery is crucial for patient outcomes.
  • Previous studies suggest varying durations of antibiotic use, necessitating further investigation into single-dose efficacy.

Purpose of the Study:

  • To evaluate the non-inferiority of single-dose antimicrobial prophylaxis compared to a 48-hour regimen in patients undergoing cardiac surgery.
  • To assess the impact of prophylaxis duration on in-hospital infection rates in this patient population.

Main Methods:

  • Prospective, non-randomized trial involving 353 consecutive cardiac surgery patients.
  • Group A (n=151) received 48-hour prophylaxis; Group B (n=202) received a single dose.
  • Antibiotic choice (Cephazolin or Teicoplanin/Timentin for MRSA risk) was standardized.

Related Experiment Videos

Main Results:

  • Overall in-hospital infection rate was 2.8%.
  • No statistically significant difference in infection rate or type was observed between the single-dose and 48-hour prophylaxis groups.
  • Targeted prophylaxis for high-risk patients (MRSA) proved effective.

Conclusions:

  • Single-dose antimicrobial prophylaxis is a viable and effective alternative to 48-hour regimens for cardiac surgery.
  • The observed infection rate of 2.8% is comparable to existing literature, supporting the efficacy of single-dose prophylaxis.
  • Strategic prophylaxis targeting high-risk individuals enhances patient safety without prolonging antibiotic exposure.