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Megestrol-induced clinical adrenal insufficiency
1Harvard Medical School Massachusetts General Hospital, Department of Obstetrics and Gynecology, Boston 02114, USA.
European Journal of Gynaecological Oncology
|June 8, 2000
Abstract
Objective:
To describe a case of megestrol-induced adrenal insufficiency.
Methods:
A patient who received megestrol and then developed pituitary-adrenal axis abnormalities is described. The literature is reviewed.
Results:
The patient developed megestrol-induced Cushingoid features. She developed adrenal insufficiency when megestrol was stopped.
Conclusion:
Megestrol can induce alterations of the pituitary-adrenal axis in some patients. It is important to consider a diagnosis of adrenal insufficiency in patients with symptoms of fatigue, hypotension, and asthenia who have been treated with megestrol.