Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bioactive 12-oleanene triterpene and secotriterpene acids from Maytenus undata.

I Muhammad1, K A El Sayed, J S Mossa

  • 1Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC) and Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Journal of Natural Products
|June 8, 2000
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Traditional knowledge about medicinal plant in the remote areas of Wari Tehsil, Dir Upper, Pakistan.

Brazilian journal of biology = Revista brasleira de biologia·2021
Same author

Poverty-associated emerging infection of Cystic Echinococcosis in population of Northern Pakistan: A hospital based study.

Tropical biomedicine·2021
Same author

Exogenous fibrolytic enzymes and recombinant bacterial expansins synergistically improve hydrolysis and in vitro digestibility of bermudagrass haylage.

Journal of dairy science·2019
Same author

Preparation and evaluation of tilmicosin microspheres and lung-targeting studies in rabbits.

Veterinary journal (London, England : 1997)·2019
Same author

A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms.

Stem cell reviews and reports·2017
Same author

A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties.

Lab on a chip·2016

Maytenus undata yielded new triterpene acids with antibacterial and anti-inflammatory properties. One compound, 20-epi-koetjapic acid, showed potent inhibition of inflammatory mediators in microglia.

Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Pharmacology

Background:

  • Maytenus undata is a plant source of bioactive compounds.
  • Triterpene acids are a class of natural products with diverse biological activities.

Purpose of the Study:

  • To isolate and characterize new triterpene acids from Maytenus undata.
  • To evaluate the antibacterial and anti-inflammatory potential of these compounds.

Main Methods:

  • Phytochemical investigation of Maytenus undata aerial parts.
  • Isolation and structure elucidation of triterpene acids using spectroscopic methods.
  • Antibacterial assays against Staphylococcus aureus and Pseudomonas aeruginosa.
  • Inhibition assays of inflammatory mediators in rat neonatal brain microglia.

Related Experiment Videos

Main Results:

  • Four new 12-oleanene and 3,4-seco-12-oleanene triterpene acids were identified.
  • Koetjapic acid demonstrated significant antibacterial activity against Gram-positive and Gram-negative bacteria.
  • 20-epi-koetjapic acid potently inhibited thromboxane B(2) and superoxide anion generation in microglia.

Conclusions:

  • Maytenus undata is a rich source of novel bioactive triterpene acids.
  • Koetjapic acid and 20-epi-koetjapic acid exhibit promising antibacterial and anti-inflammatory activities, respectively.
  • These findings suggest potential therapeutic applications for Maytenus undata-derived compounds.