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Bioactive 12-oleanene triterpene and secotriterpene acids from Maytenus undata
I Muhammad1, K A El Sayed, J S Mossa
1Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC) and Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Journal of Natural Products
|June 8, 2000
Summary
Maytenus undata yielded new triterpene acids with antibacterial and anti-inflammatory properties. One compound, 20-epi-koetjapic acid, showed potent inhibition of inflammatory mediators in microglia.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Pharmacology
Background:
- Maytenus undata is a plant source of bioactive compounds.
- Triterpene acids are a class of natural products with diverse biological activities.
Purpose of the Study:
- To isolate and characterize new triterpene acids from Maytenus undata.
- To evaluate the antibacterial and anti-inflammatory potential of these compounds.
Main Methods:
- Phytochemical investigation of Maytenus undata aerial parts.
- Isolation and structure elucidation of triterpene acids using spectroscopic methods.
- Antibacterial assays against Staphylococcus aureus and Pseudomonas aeruginosa.
- Inhibition assays of inflammatory mediators in rat neonatal brain microglia.
Main Results:
- Four new 12-oleanene and 3,4-seco-12-oleanene triterpene acids were identified.
- Koetjapic acid demonstrated significant antibacterial activity against Gram-positive and Gram-negative bacteria.
- 20-epi-koetjapic acid potently inhibited thromboxane B(2) and superoxide anion generation in microglia.
Conclusions:
- Maytenus undata is a rich source of novel bioactive triterpene acids.
- Koetjapic acid and 20-epi-koetjapic acid exhibit promising antibacterial and anti-inflammatory activities, respectively.
- These findings suggest potential therapeutic applications for Maytenus undata-derived compounds.