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Interleukin 15 is a growth factor for human thymocytes with preferential effect on CD8(+)cells
S Thulesen1, M Nielsen, T R Petersen
1Institute of Medical Anatomy Section A, The Panum Institute, University of Copenhagen, Copenhagen, Denmark.
Cytokine
|June 14, 2000
Abstract:
The effects of IL-15, as compared to IL-2, on growth of human thymocytes has been evaluated. Expression of comparable amounts of receptor chains was found on IL-2 and IL-15 cultured thymocytes, as well as comparable receptor signalling. However, IL-15 was superior to IL-2 in promoting CD8(+)thymocyte growth, whereas CD4(+)cells proliferated to a higher extent in IL-2 cultures. CD4(+)8(+)and CD4(-)8(-)thymocytes expanded equally well in both culture types.