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Related Experiment Videos

Prostatic disorders in the dog.

S D Johnston1, K Kamolpatana, M V Root-Kustritz

  • 1College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA 91766-1854, USA. sjohnston@westernu.edu

Animal Reproduction Science
|June 14, 2000
PubMed
Summary
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Benign prostatic hypertrophy (BPH) affects over 80% of intact male dogs over 5 years old. Finasteride treatment can help manage BPH and related conditions by reducing testosterone conversion.

Area of Science:

  • Veterinary Medicine
  • Canine Urology
  • Oncology

Background:

  • Canine prostatic disorders are common, including benign prostatic hypertrophy (BPH), prostatitis, cysts, and adenocarcinoma.
  • BPH affects over 80% of intact male dogs older than 5 years, presenting with signs like bloody prostatic fluid, constipation, and difficult urination.
  • BPH often co-occurs with other prostatic conditions such as infection, abscesses, cysts, and neoplasia.

Purpose of the Study:

  • To summarize common canine prostatic disorders.
  • To discuss the efficacy of finasteride in treating BPH and associated conditions.
  • To explore the potential link between prostatic intraepithelial neoplasia (PIN) and adenocarcinoma in dogs.

Main Methods:

  • Review of existing literature on canine prostatic diseases.

Related Experiment Videos

  • Analysis of BPH pathophysiology and treatment responses.
  • Examination of studies on canine prostatic adenocarcinoma and PIN.

    • Main Results:

    • BPH is a prevalent, age-related condition in intact male dogs.
    • Finasteride treatment effectively reduces BPH by inhibiting dihydrotestosterone production, leading to apoptosis and prostatic involution.
    • Finasteride may benefit concurrent prostatic conditions, excluding neoplasia.
    • Studies indicate a potential increased risk of prostatic adenocarcinoma in neutered dogs.
    • Prostatic intraepithelial neoplasia (PIN) is frequently observed in older male dogs and may be a precursor to adenocarcinoma.

    Conclusions:

    • Finasteride is a viable treatment for canine BPH and associated disorders, except neoplasia.
    • The relationship between neutering status and prostatic adenocarcinoma risk warrants further investigation.
    • PIN may serve as a precursor to canine prostatic adenocarcinoma, similar to its role in humans.