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Coma-induced bullae and sweat gland necrosis following clobazam
J F Setterfield1, R Robinson, D MacDonald
1Department of Oral Medicine, Department of Paediatrics, Guy's Hospital, and St John's Institute of Dermatology, St Thomas' Hospital, London, UK. j.setterfield@umds.ac.uk
Clinical and Experimental Dermatology
|June 9, 2000
Abstract:
Coma-induced bullae and sweat gland necrosis is a rare clinicopathological entity described in association with a variety of aetiopathological conditions all of which have resulted in an impairment of conscious level. We report the first case observed in association with clobazam, used as adjunctive therapy for resistant epilepsy in a 4-year old. The potential underlying mechanisms and previously reported associations are discussed.