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Thyroidectomy modulates rat prostatic monosaccharides.

R R Maran1, B Senthilkumaran, R C Udhayakumar

  • 1Department of Endocrinology, Dr ALM P.G. Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600 113, India. rmanimaran@hotmail.com

International Journal of Andrology
|June 9, 2000
PubMed
Summary
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Thyroid hormones significantly alter prostate glycoprotein metabolism, with hypothyroidism causing lobe-specific changes in monosaccharide and fructose levels. Thyroid hormone replacement partially restored these levels in vitro.

Area of Science:

  • Endocrinology
  • Urology
  • Biochemistry

Background:

  • Thyroid hormones are known to influence glycoprotein metabolism.
  • The specific effects of thyroid hormones on prostatic glycoprotein composition remain incompletely understood.

Purpose of the Study:

  • To investigate the impact of hypothyroidism on prostatic glycoprotein-associated monosaccharides and fructose concentrations in peripubertal rats.
  • To elucidate the direct effects of thyroid hormones on these prostatic components.

Main Methods:

  • Hypothyroidism was induced surgically in rats, with confirmation via radioimmunoassay (RIA) for thyroid hormones and thyroid-stimulating hormone (TSH).
  • Prostatic tissues were analyzed 30 and 60 days post-thyroidectomy.
  • In vitro incubation of prostatic tissue with varying doses of triiodothyronine (T3) was performed.

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Main Results:

  • Hypothyroidism led to decreased hexosamines and sialic acid in the ventral prostate, and decreased fucose and fructose in the anterior prostate.
  • The dorsolateral prostate showed increased hexosamines but decreased fucose, sialic acid, and fructose under hypothyroidism.
  • In vitro T3 treatment increased fucose, sialic acid, and hexosamines across all lobes, and fructose in the anterior and dorsolateral prostates.

Conclusions:

  • Thyroid hormone influence on prostatic monosaccharide composition is lobe-specific and sugar-specific.
  • Thyroid hormones play a differential regulatory role in prostatic glycoprotein metabolism.