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Clinical and molecular findings in multiple sclerosis patients with type 1 diabetes mellitus

Wandinger1, Trillenberg, Klüter

  • 1Institute of Immunology and Transfusion Medicine, Department of Neurology, University of Lübeck School of Medicine, Ratzeburger Allee 160, Lübeck, 23538, Germany

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|June 9, 2000
PubMed

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Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
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Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
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