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DNA typing and microsatellite associated sequence amplification (MASA) in detecting loss or gain of alleles
1Molecular Genetics Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India.
Indian Journal of Biochemistry & Biophysics
|June 9, 2000
Abstract:
Constant exposure of genomic DNA to a variety of damaging agents including radiations poses a major challenge for developing an experimental approach for monitoring such damages. No single approach can be used to address this issue. In the present article, we have provided examples of DNA typing and believe that various approaches may enable to uncover not only loss or gain(s) of the alleles but also reveal subtle changes in the genome. Similarly, our genome analysis of the animal systems provides a method to assess the effects of radiation on domestic animals.