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Updated: Jul 11, 2026

Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells
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Peripheral vascular endothelial dysfunction and apoptosis in old monkeys.

K Asai1, R K Kudej, Y T Shen

  • 1Weis Center for Research, Pennsylvania State University, College of Medicine, Danville 17822-2601, USA.

Arteriosclerosis, Thrombosis, and Vascular Biology
|June 10, 2000
PubMed
Summary

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Aging impairs vascular endothelial function in macaques, evidenced by reduced vasodilation responses to acetylcholine. This dysfunction is linked to increased endothelial cell apoptosis and lower cell density, not atherosclerosis.

Area of Science:

  • Cardiovascular Physiology
  • Aging Research
  • Vascular Biology

Background:

  • Aging is associated with cardiovascular changes.
  • Vasoactivity and endothelial function are critical for vascular health.
  • Primate models offer insights into human aging processes.

Purpose of the Study:

  • To investigate the impact of aging on vasoactivity in a primate model (Macaca fascicularis).
  • To identify potential mechanisms underlying age-related vascular dysfunction.

Main Methods:

  • Comparison of young (7.1 years) and old (19.8 years) male macaques.
  • Chronic instrumentation for hemodynamic measurements (pressures, cardiac output).
  • Assessment of vascular response to acetylcholine and sodium nitroprusside; histological analysis for endothelial apoptosis and cell density.
Keywords:
Non-programmatic

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Last Updated: Jul 11, 2026

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Main Results:

  • No significant differences in baseline hemodynamics or metabolic markers between age groups.
  • Old monkeys showed reduced vasodilation (less fall in total peripheral resistance) to acetylcholine compared to young monkeys.
  • Endothelial cell apoptosis was increased in old monkeys' aortas and femoral arteries, correlating with reduced endothelial cell density and impaired acetylcholine response.

Conclusions:

  • Aging leads to vascular endothelial dysfunction in macaques, independent of atherosclerosis.
  • Increased endothelial apoptosis and reduced endothelial cell density are potential contributors to this dysfunction.
  • These findings highlight age-related changes in vascular reactivity and cellular integrity.