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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
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Drug related clinical pattern in fixed drug eruption

E Ozkaya-Bayazit1, H Bayazit, G Ozarmagan

  • 1Department of Dermatology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey. ebayazit@istanbul.edu.tr

European Journal of Dermatology : EJD
|June 10, 2000
PubMed

Insights

Fixed drug eruption (FDE) is common in Turkey, with cotrimoxazole being the most frequent cause. This study found cotrimoxazole-induced FDE often appeared on male genitalia, though drug-specific patterns were not definitively established.

Area of Science:

  • Dermatology
  • Pharmacology
  • Clinical Medicine

Background:

  • Fixed drug eruption (FDE) is a common adverse drug reaction.
  • Understanding drug-specific patterns in FDE is crucial for diagnosis and management.

Purpose of the Study:

  • To analyze the clinical features of FDE in a Turkish case series.
  • To investigate potential drug-related patterns in FDE presentation.
  • To identify the most common causative agents of FDE.

Main Methods:

  • Prospective open study evaluating 64 patients with established FDE.
  • Clinical assessment including oral provocation tests.
  • Analysis of drug offenders and lesion localization.

Main Results:

  • Cotrimoxazole was the most frequent cause of FDE (75%).
  • Naproxen, dipyrone, dimenhydrinate, and paracetamol were less common offenders.
  • Cotrimoxazole-induced FDE predominantly affected male genitalia; naproxen affected the face/lips; dipyrone affected the trunk/extremities.
  • A significant difference in trunk/extremity involvement was noted between dipyrone and cotrimoxazole (p=0.03).
  • Unusual FDE presentations were observed with cotrimoxazole.

Conclusions:

  • Cotrimoxazole is the leading cause of FDE in this series.
  • While some drug-associated localizations were observed, a significant relationship between specific drugs and FDE clinical patterns could not be definitively established.
  • Rare presentations of cotrimoxazole-induced FDE were documented.

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