Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Limits of resistance testing.

R T D'Aquila1

  • 1Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA. rdaquila@partners.org

Antiviral Therapy
|June 10, 2000
PubMed
Summary

Interpreting antiretroviral resistance tests for HIV can be complex due to biology and drug pressure. Understanding these factors improves the accuracy of resistance testing for personalized HIV treatment choices.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations of CCR5, CCR2, and stromal cell-derived factor 1 genotypes with human immunodeficiency virus disease progression in patients receiving nucleoside therapy.

The Journal of infectious diseases·2001
Same author

Human immunodeficiency virus type 1 hypersusceptibility to amprenavir in vitro can be associated with virus load response to treatment in vivo.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2001
Same author

HIV-1 drug resistance profiles in children and adults with viral load of <50 copies/ml receiving combination therapy.

JAMA·2001
Same author

Clinical use of genotypic and phenotypic drug resistance testing to monitor antiretroviral chemotherapy.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2001
Same author

Indinavir, nevirapine, stavudine, and lamivudine for human immunodeficiency virus-infected, amprenavir-experienced subjects: AIDS Clinical Trials Group protocol 373.

The Journal of infectious diseases·2001
Same author

Clinical monitoring of HIV-1 infection in the ERA of antiretroviral resistance testing.

Infectious disease clinics of North America·2001

Area of Science:

  • Virology
  • Pharmacology
  • Clinical Medicine

Background:

  • Antiretroviral therapy is crucial for managing HIV infection.
  • Interpreting antiretroviral resistance testing results presents challenges.
  • Factors influencing test interpretation include HIV biology, genetics, and drug selection pressure.

Purpose of the Study:

  • To elucidate the complexities in interpreting antiretroviral resistance testing.
  • To highlight how biological and genetic factors impact test outcomes.
  • To guide clinicians in optimizing the use of resistance testing for individualized treatment.

Main Methods:

  • Review of factors affecting antiretroviral resistance testing.
  • Analysis of HIV biology and genetic influences.
  • Examination of in vivo drug selection pressure dynamics.

Main Results:

  • Complexities in HIV biology and genetics can limit resistance test utility.
  • In vivo drug selection pressure introduces further interpretive challenges.
  • Accurate interpretation requires understanding these multifaceted influences.

Conclusions:

  • Knowledge of complicating factors is essential for avoiding misinterpretation of resistance tests.
  • Effective use of resistance testing aids in personalizing antiretroviral drug selection.
  • Improved interpretation enhances the clinical utility of resistance testing in HIV management.

Related Experiment Videos