Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple sclerosis in Australia: prognostic factors.

S R Hammond1, J G McLeod, P Macaskill

  • 1Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, University of Sydney, Australia.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|June 10, 2000
PubMed
Summary

Older age of onset, progressive multiple sclerosis (MS) course, and specific initial symptoms like pyramidal or cerebellar indicate a worse prognosis. A shorter interval to the first relapse also predicts poorer outcomes in MS patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Vitamin D Supplementation on Telomere Length: An Analysis of Data from the Randomised Controlled D-Health Trial.

The journal of nutrition, health & aging·2023
Same author

Trajectories of body mass index from early adulthood to late midlife and incidence of total knee arthroplasty for osteoarthritis: findings from a prospective cohort study.

Osteoarthritis and cartilage·2022
Same author

Analgesic use and the risk of renal cell carcinoma - Findings from the Consortium for the Investigation of Renal Malignancies (CONFIRM) study.

Cancer epidemiology·2021
Same author

Recent Studies of the Nervous System.

Journal of the Royal College of Physicians of London·2019
Same author

Coffee, tea, and caffeine intake and amyotrophic lateral sclerosis mortality in a pooled analysis of eight prospective cohort studies.

European journal of neurology·2018
Same author

Dietary inflammatory index or Mediterranean diet score as risk factors for total and cardiovascular mortality.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2018

Area of Science:

  • Neurology
  • Epidemiology

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease with variable progression.
  • Understanding prognostic factors is crucial for managing MS patient outcomes.

Purpose of the Study:

  • To identify predictors of disability progression in a large Australian multiple sclerosis cohort.
  • To analyze the influence of age of onset, sex, onset symptoms, clinical course, and time to first relapse on subsequent MS disability.

Main Methods:

  • Analysis of data from 2934 Australian multiple sclerosis cases.
  • Disability assessed using the Kurtzke Disability Status (DSS) scale (mild, moderate, severe).
  • Logistic regression used to identify prognostic factors for disability levels.

Main Results:

Related Experiment Videos

  • Worse prognosis significantly associated with older age of onset.
  • Progressive disease course, and onset symptoms (multiple, pyramidal, or cerebellar) correlated with poorer outcomes.
  • A short interval from onset to first relapse was a significant predictor of worse disability.

Conclusions:

  • Early identification of prognostic factors in multiple sclerosis can aid in predicting disease trajectory.
  • Factors such as age at onset, disease course, initial symptoms, and relapse patterns are key indicators for MS prognosis.