Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The optic nerve head in normal-tension glaucoma.

G Tomita1

  • 1Department of Ophthalmology, University of Tokyo School of Medicine, Japan. gtom-gif@umin.ac.jp

Current Opinion in Ophthalmology
|June 10, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adverse periocular reactions to five types of prostaglandin analogs.

Eye (London, England)·2012
Same author

Evaluation of the effect of aging on the retinal nerve fiber layer thickness using scanning laser polarimetry.

Journal of glaucoma·2009
Same author

Atypical retardation pattern in measurements of scanning laser polarimetry and its relating factors.

Eye (London, England)·2008
Same author

Performance of GDx VCC in eyes with peripapillary atrophy: comparison of three circle sizes.

Eye (London, England)·2006
Same author

Optic disc topographic parameters measured in the normal cynomolgus monkey by confocal scanning laser tomography.

The British journal of ophthalmology·2005
Same author

Topical application of autologous serum for the treatment of late-onset aqueous oozing or point-leak through filtering bleb.

Eye (London, England)·2004

Normal-tension glaucoma (NTG) presents unique optic nerve head characteristics, differing from primary open-angle glaucoma. Novel findings include specific autoantibodies in NTG patients, suggesting autoimmune involvement in optic nerve damage.

Area of Science:

  • Ophthalmology
  • Neuroscience

Background:

  • The definition and characteristics of the optic nerve head in normal-tension glaucoma (NTG) remain debated.
  • Optic disk size is generally larger in NTG compared to primary open-angle glaucoma (POAG).

Purpose of the Study:

  • To investigate the controversial definition and characteristics of the optic nerve head in NTG.
  • To explore novel histopathologic and serologic findings in NTG patients.

Main Methods:

  • Comparative analysis of optic disk size and glaucomatous damage in NTG versus POAG.
  • Evaluation of optic disk hemorrhage, peripapillary atrophy, and their association with visual field loss progression in NTG.
  • Histopathologic examination of optic nerve heads.
  • Detection of serum antibodies to retinal proteins and optic nerve head glycosaminoglycans.

Related Experiment Videos

Main Results:

  • Intraindividual comparisons showed no correlation between larger optic disk size and severity of glaucomatous damage in NTG.
  • Optic disk hemorrhage and peripapillary atrophy were more frequent in NTG and associated with visual field loss progression.
  • Histopathology revealed comparable optic nerve head changes in NTG and POAG.
  • Novel findings include serum antibodies to retinal proteins, retinal immunoglobulin deposition, and elevated serum autoantibodies to optic nerve head glycosaminoglycans in NTG patients.

Conclusions:

  • Optic nerve head appearance in NTG is distinct, with larger disks but comparable damage severity to POAG.
  • Factors like disk hemorrhage and atrophy are significant in NTG progression.
  • Emerging evidence suggests a potential autoimmune component in the pathogenesis of NTG.