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Updated: Aug 1, 2026
Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program
Published on: February 25, 2015
Correlation structure of end-expiratory lung volume in anesthetized rats with intact upper airway
1Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506, USA. xizhan0@sac.uky.edu
Abstract:
The correlation structure of breath-to-breath fluctuations of end-expiratory lung volume (EEV) was studied in anesthetized rats with intact airways subjected to positive and negative transrespiratory pressure (i.e., PTRP and NTRP, correspondingly). The Hurst exponent, H, was estimated from EEV fluctuations using modified dispersional analysis. We found that H for EEV was 0.5362 +/- 0.0763 and 0.6403 +/- 0.0561 with PTRP and NTRP, respectively (mean +/- SD). Both H were significantly different from those obtained after random shuffling of the original time series. Also, H with NTRP was significantly greater than that with PTRP (P = 0.029). We conclude that in rats breathing through the upper airway, a positive long-term correlation is present in EEV that is different between PTRP and NTRP.
