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Related Experiment Videos

Nailfold video capillaroscopy in psoriasis.

M Bhushan1, T Moore, A L Herrick

  • 1Dermatology Centre and Centre for Rheumatic Diseases, University of Manchester, Hope Hospital, Salford, Manchester M6 8HD, U.K. mbhushan@fs1.ho.man.ac.uk

The British Journal of Dermatology
|June 10, 2000
PubMed
Summary

Nailfold video capillaroscopy revealed reduced capillary density in psoriasis patients with nail or joint involvement. Capillary dimensions were smaller in psoriatic arthritis patients, suggesting vascular injury contributes to disease pathogenesis.

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Area of Science:

  • Dermatology
  • Rheumatology
  • Microcirculation Research

Background:

  • Microvascular changes are implicated in the pathogenesis of psoriasis and psoriatic arthritis.
  • Nailfold video capillaroscopy, an extension of nailfold microscopy, studies in vivo microcirculation.
  • Previous studies on nailfold capillaries in psoriasis patients yielded conflicting results.

Purpose of the Study:

  • To investigate nailfold capillary abnormalities in psoriasis patients, particularly those with adjacent nailfold pathology.
  • To test if quantitative or qualitative capillary changes are more evident in subjects with distal interphalangeal (DIP) joint changes and/or nail dystrophy.

Main Methods:

  • Recruited 44 patients with psoriasis (varying degrees of nail and DIP joint involvement) and 44 age- and sex-matched controls.

Related Experiment Videos

  • Utilized nailfold video capillaroscopy to assess capillary loop density and dimensions.
  • Compared capillary parameters between patient groups and controls.

    • Main Results:

    • Significantly decreased capillary loop density observed in psoriasis patients with nail disease or with both nail and DIP joint disease compared to controls.
    • Reduced arterial and venous capillary limb diameters found in psoriatic arthritis patients with DIP joint involvement and those with arthritis associated with nail changes.
    • No significant difference in capillary dimensions between psoriasis patients (with or without nail changes) and normal controls.
    • No specific morphological abnormalities were noted in any patient group.

    Conclusions:

    • Diminished nailfold capillary bed density and dimensions in psoriasis patients suggest vascular injury may contribute to psoriatic arthritis pathogenesis.
    • Unlike some prior studies, no specific morphological pattern of nailfold capillaries was identified in psoriasis patients compared to controls.