Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gastrotonometry represents dramatic increase in PcO2 after acetazolamide administration.

K Taki1, K Oogushi, K Tozuka

  • 1Department of Emergency Medicine, Saga Medical College, Saga, Japan.

European Journal of Clinical Investigation
|June 10, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The clinical impact of preoperative body composition differs between male and female colorectal cancer patients.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2019
Same author

The impact of preoperative anaemia and anaemic subtype on patient outcome in colorectal cancer.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2018
Same author

Transcatheter embolization for the management of traumatic coronary venous injury.

Diagnostic and interventional imaging·2018
Same author

Cross-cultural comparison of breast cancer patients' Quality of Life in the Netherlands and Japan.

Breast cancer research and treatment·2017
Same author

Note: Development of real-time epithermal neutron detector for boron neutron capture therapy.

The Review of scientific instruments·2017
Same author

Education and Imaging. Hepatobiliary and Pancreatic: Replaced common hepatic artery on left gastric artery: a rare anomaly and implication for pancreaticoduodenectomy.

Journal of gastroenterology and hepatology·2016

Acetazolamide significantly increases tissue CO2 levels (PtCO2) by affecting carbonic anhydrase, while arterial CO2 (PaCO2) remains stable. Gastrotonometry can monitor these changes, serving as a warning for acetazolamide use in vulnerable patients.

Area of Science:

  • Physiology
  • Pharmacology
  • Biochemistry

Background:

  • Investigating carbonic anhydrase role in CO2 transport.
  • Evaluating CO2 transport during acetazolamide administration.

Purpose of the Study:

  • Assess carbonic anhydrase's role in CO2 transport.
  • Monitor CO2 parameters during acetazolamide administration.

Main Methods:

  • Monitored tissue (PtCO2), arterial (PaCO2), and end-tidal (PETCO2) CO2.
  • Studied CO2 correlations post-acetazolamide IV in healthy volunteers.

Main Results:

  • PtCO2 peaked >60 mmHg, remaining elevated.
  • PaCO2 unchanged; PETCO2 significantly decreased.
  • Minute ventilation increased progressively.

Related Experiment Videos

Conclusions:

  • Gastrotonometry monitors acetazolamide-induced PtCO2 increase.
  • Potential warning for acetazolamide in patients lacking ventilation/circulation reserve.