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Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein
C Lyngsø1, G Bouteiller, C K Damgaard
1Department of Molecular and Structural Biology, University of Aarhus, C. F. Mollers Alle 130, DK-8000 Aarhus C., Denmark.
The Journal of Biological Chemistry
|June 13, 2000
Abstract:
The activator of stromelysin 1 gene transcription, SPBP, interacts with the RING finger protein RNF4. Both proteins are ubiquitously expressed and localized in the nucleus. RNF4 facilitates accumulation of specific SPBP-DNA complexes in vitro and acts as a positive cofactor in SPBP-mediated transactivation. SPBP harbors an internal zinc finger of the PHD/LAP type. This domain can form intra-chain protein-protein contacts in SPBP resulting in negative modulation of SPBP-RNF4 interaction.