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Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
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Inhibition of DNA methyltransferase inhibits DNA replication

J D Knox1, F D Araujo, P Bigey

  • 1Department of Pharmacology and Therapeutics, the McGill Cancer Centre, McGill University, 3655 Sir William Osler Promenade, Montreal, Quebec H3G 1Y6, Canada.

The Journal of Biological Chemistry
|June 13, 2000
PubMed
Summary

DNA methyltransferase (DMT) is essential for DNA replication in lung cancer cells. Inhibiting DMT disrupts DNA synthesis and cell cycle progression, impacting DNA replication origins.

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