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A genomic model for differential hypoxic ventilatory responses.

C G Tankersley1

  • 1Division of Physiology, Johns Hopkins School of Public Health, USA.

Advances in Experimental Medicine and Biology
|June 13, 2000
PubMed
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Genetic differences in hypoxic ventilatory responses (HVR) between mouse strains are not linked to baseline breathing patterns. Two major genes likely regulate HVR, impacting breathing frequency during hypoxia.

Area of Science:

  • Genetics
  • Physiology
  • Respiratory Biology

Background:

  • Inbred mice are crucial genetic models in lung biology research.
  • Significant differences exist in lung function and structure between C3H/HeJ (C3) and C57BL/6J (B6) mice.
  • These strains exhibit distinct ventilatory patterns during acute hypoxic challenges.

Purpose of the Study:

  • To investigate the genetic basis of differential hypoxic ventilatory responses (HVR) between C3 and B6 mice.
  • To test the hypothesis that HVR genetic loci are linked to baseline breathing patterns.
  • To propose an alternative genetic model for HVR variation.

Main Methods:

  • Utilized twelve BXH recombinant inbred (RI) strains derived from C3 and B6 progenitors.
  • Assessed HVR in 134 mice using whole-body plethysmography.

Related Experiment Videos

  • Measured tidal volume (VT) and breathing frequency (f) during hypoxic conditions.

    • Main Results:

    • Identified three distinct phenotypes for breathing frequency (f) during hypoxia in the BXH RI strain distribution pattern (SDP).
    • The SDP for hypoxic f supports a two-gene model for parental strain differences.
    • Genetic control of breathing frequency during hypoxia differs from baseline breathing patterns.

    Conclusions:

    • Rejects the hypothesis linking HVR genetic basis to baseline breathing pattern loci.
    • Proposes that two major genetic determinants regulate phenotypic variation in HVR, particularly breathing frequency during hypoxia.
    • Minute ventilation (VE) during hypoxia is primarily determined by tidal volume (VT).