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Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
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Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13

M J Seraj1, R S Samant, M F Verderame

  • 1Jake Gittlen Cancer Research Institute, The Pennsylvania State University College of Medicine, Hershey 17033-2390, USA.

Cancer Research
|June 13, 2000
PubMed

Insights

A novel gene, breast-cancer metastasis suppressor 1 (BRMS1), identified on human chromosome 11, significantly reduces breast cancer metastasis. This discovery offers new insights into controlling cancer spread without affecting tumor growth.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Human chromosome 11 introduction reduced MDA-MB-435 breast carcinoma cell metastasis by 70-90%.
  • This suggests metastasis suppressor genes are located on chromosome 11.

Purpose of the Study:

  • To identify genes responsible for metastasis suppression on human chromosome 11.
  • To isolate and functionally characterize novel metastasis suppressor genes.

Main Methods:

  • Differential display was used to compare gene expression between chromosome 11-containing and parental metastatic cells.
  • Isolation and functional characterization of a full-length cDNA for a novel gene, breast-cancer metastasis suppressor 1 (BRMS1).

Main Results:

  • BRMS1 was identified and mapped to human chromosome 11q13.1-q13.2.
  • Stably transfected breast carcinoma cells (MDA-MB-435 and MDA-MB-231) expressing BRMS1 showed significantly reduced metastasis to lungs and lymph nodes.
  • Tumorigenicity and local invasiveness remained unaffected.

Conclusions:

  • Breast-cancer metastasis suppressor 1 (BRMS1) is a novel mediator of metastasis suppression in human breast carcinoma.
  • BRMS1 functions to inhibit cancer cell spread without impacting primary tumor growth.

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