Related Experiment Video
Updated: Oct 16, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Drug-induced linear immunoglobulin A bullous disease that clinically mimics toxic epidermal necrolysis
M Z Mofid1, C Costarangos, B Bernstein
1Department of Dermatology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA.
Abstract:
Drug-induced linear immunoglobulin A bullous disease is a subepidermal blistering disorder that most commonly occurs after exposure to vancomycin. It can clinically mimic toxic epidermolytic necrolysis. We describe an 87-year-old white woman in whom linear immunoglobulin A bullous disease developed while she was taking vancomycin and phenytoin. A few days after the linear immunoglobulin A bullous disease developed, both medications were discontinued. No new bullae developed, and the eruption completely resolved within 2 weeks. The patient was treated with only topical therapy.
Related Concept Videos
Drug Toxicity: Allergic Reactions
Inflammatory Bowel Disease II: Ulcerative Colitis
Hypersensitivity Reactions: Immune-Complex Reactions
Hypersensitivity Reactions: Cytolytic Reactions
Allergic Drug Reactions
Inflammatory Bowel Disease III: Crohn's Disease
