Related Experiment Videos
Synechocystis strain PCC 6803 cya2, a prokaryotic gene that encodes a guanylyl cyclase
J A Ochoa De Alda1, G Ajlani, J Houmard
1Dynamique des Membranes Végétales, Complexes Protéines-Pigments, CNRS UMR8543, Ecole Normale Supérieure, 75230 Paris Cedex 05, France. jhoumard@biologie.ens.fr
Journal of Bacteriology
|June 13, 2000
Abstract:
Synechocystis strain PCC 6803 exhibits similar levels of cyclic AMP (cAMP) and cyclic GMP (cGMP). A thorough analysis of its genome showed that Cya2 (Sll0646) has all the sequence determinants required in terms of activity and purine specificity for being a guanylyl cyclase. Insertional mutagenesis of cya2 caused a marked reduction in cGMP content without altering the cAMP content. Thus, Cya2 represents the first example of a prokaryotic guanylyl cyclase.