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Molecular determinants of presynaptic active zones
C C Garner1, S Kindler, E D Gundelfinger
1Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294-0021, USA. garner@nrc.uab.edu
Current Opinion in Neurobiology
|June 14, 2000
Abstract:
The presynaptic cytoskeletal matrix (cytomatrix) assembled at active zones has been implicated in defining neurotransmitter release sites. Munc13, Rim, Bassoon and Piccolo/Aczonin are recently identified presynaptic cytomatrix proteins. These multidomain proteins are thought to organize the exocytotic and endocytotic machinery precisely at active zones.