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Structural genomics of microbes: an objective.

S H Kim1

  • 1Calvin Laboratory, University of California, Berkeley, CA 94720, USA.

Current Opinion in Structural Biology
|June 14, 2000
PubMed
Summary

Many microbial genes have unknown functions. Determining protein structures from these genes can reveal their molecular functions and novel protein folds, aiding in understanding complex organisms.

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Area of Science:

  • Genomics
  • Proteomics
  • Structural Biology

Background:

  • A significant proportion of genes across numerous microbial genomes encode proteins with uncharacterized functions.
  • Understanding these unknown proteins is crucial for advancing molecular biology and discovering novel protein structures.

Purpose of the Study:

  • To investigate the potential of determining protein structures to elucidate the functions of genes with unknown roles.
  • To explore the discovery of new protein fold patterns through structural analysis.

Main Methods:

  • Comparative genomics analysis of over 20 microbial genomes.
  • Protein structure determination using existing technological advancements.
  • Generation of complete sequence and near-complete structural complements for small microbial genomes.

Main Results:

  • Identification of a large fraction of genes with unknown functions across diverse microorganisms.
  • Demonstration that protein structure determination can provide insights into molecular functions.
  • Feasibility of obtaining comprehensive genomic and structural data for small microbial systems.

Conclusions:

  • Structural proteomics offers a powerful approach to deciphering the functions of unannotated genes.
  • Small microbial genomes serve as valuable models for understanding biological complexity.
  • This approach can accelerate the discovery of novel protein folds and functions.

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