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Related Experiment Videos

Long-Term Combined Androgen Blockade Alone for Localized Prostate Cancer.

Labrie1, Cusan, Gomez

  • 1Prostate Cancer Clinical Research Unit, Department of Medicine and Laboratory of Oncology and Molecular Endocrinology, Laval University Medical Research Center, Centre Hospitalier Universitaire de Québec, Québec, Canada.

Molecular Urology
|June 14, 2000
PubMed
Summary

Long-term continuous combined androgen blockade (CAB) is effective for localized prostate cancer. This treatment, alone, shows high efficacy, with most patients maintaining undetectable PSA levels, highlighting the need for extended therapy.

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Area of Science:

  • Urology
  • Oncology
  • Medical research

Background:

  • Prostate cancer treatment options are limited for patients unwilling or unable to undergo radical prostatectomy or radiotherapy.
  • Combined androgen blockade (CAB) is a therapeutic strategy that targets androgen signaling pathways in prostate cancer.

Purpose of the Study:

  • To evaluate the long-term efficacy of continuous combined androgen blockade (CAB) as a monotherapy for localized prostate cancer (stages T(2) and T(3)).

Main Methods:

  • A cohort of 26 patients with stage T(2) and 115 patients with stage T(3) prostate cancer received continuous CAB (LHRH agonist and flutamide).
  • Treatment duration and follow-up periods were recorded, with serum prostate-specific antigen (PSA) levels monitored to assess cancer progression.
  • Cessation of CAB was analyzed in subgroups to determine the durability of treatment effects.

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Main Results:

  • In stage T(2) patients, only one of 26 experienced PSA progression after 7.3 years of CAB. Following cessation, 2 of 20 patients showed failure, with one death from prostate cancer.
  • In stage T(3) patients, 19% (5 of 26) experienced PSA failure after continuous CAB for a median of 9.9 years.
  • Overall, 85% of patients with stage T(2)-T(3) disease maintained undetectable PSA levels during extended follow-up after long-term CAB therapy.

Conclusions:

  • Continuous combined androgen blockade (CAB) demonstrates high efficacy as a standalone treatment for localized prostate cancer (stages T(2)-T(3)).
  • Long-term treatment with CAB is crucial for sustained disease control, comparable to established durations for other hormonal therapies like tamoxifen for breast cancer.