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[Cell receptors for human adenoviruses]
1Laboratoire de Virologie et Pathogenèse Moléculaire, Faculté de Médecine de Montpellier, CNRS UMR 5812, Montpellier.
Journal De La Societe De Biologie
|June 14, 2000
Summary
Adenovirus uses specific cell receptors for infection, with CAR and MHC-I-alpha 2 being key. Fiber knob structure dictates which receptor the virus binds, impacting gene therapy applications.
Area of Science:
- Virology
- Molecular Biology
- Immunology
Context:
- Adenovirus infection initiates with virion binding to primary receptors on host cells.
- This binding involves fiber projections from penton base capsomers.
- Secondary receptor engagement via integrins and penton base motifs follows, crucial for endocytosis.
Purpose:
- To identify and characterize the primary receptors utilized by adenovirus for cell entry.
- To elucidate the viral and cellular factors governing adenovirus receptor usage.
- To map the viral determinants responsible for differential receptor binding.
Summary:
- Two primary adenovirus receptors identified: Coxsackievirus and Adenovirus Receptor (CAR) and a region of MHC-I-alpha 2.
- CAR is tissue-specific (mesodermic), while MHC-I-alpha 2 is ubiquitous.
- Adenovirus fiber knob structure dictates binding specificity: CAR recognizes linear motifs (except subgroup B), MHC-I-alpha 2 recognizes conformational epitopes (including subgroup B).
Impact:
- Understanding adenovirus-receptor interactions is crucial for developing targeted gene therapy vectors.
- Differential receptor usage informs strategies for directing adenoviral vectors to specific cell types.
- Findings have implications for controlling adenovirus tropism in therapeutic applications.