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Updated: Jul 22, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
An acquired factor V inhibitor: clinical and laboratory features
1State University of New York at Buffalo, USA.
An acquired Factor V inhibitor, a rare bleeding disorder, can develop after infection or medication. This condition requires prompt diagnosis and treatment to prevent serious complications.
Area of Science:
- Hematology
- Internal Medicine
- Clinical Immunology
Background:
- Acquired Factor V inhibitors are rare autoimmune disorders.
- Cholecystitis and cefotaxime therapy are potential triggers.
- Factor V activity less than 1% indicates severe coagulopathy.
Observation:
- A 65-year-old male presented with symptoms of acquired Factor V inhibitor.
- He experienced lower gastrointestinal bleeding.
- The condition mimicked a lupus anticoagulant but caused bleeding.
Findings:
- Laboratory studies confirmed an IgG inhibitor to Factor V.
- Treatment with plasmapheresis, fresh frozen plasma, cyclophosphamide, and prednisone was initiated.
- Coagulopathy resolved within four days of treatment.
Implications:
- Clinicians should be aware of acquired Factor V inhibitors.
- Distinguishing it from lupus anticoagulant is crucial due to bleeding risk.
- Prompt treatment is necessary before surgical procedures.
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