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Related Experiment Videos

Changes in adrenocortical function with aging and therapeutic implications.

A J Harper1, J E Buster, P R Casson

  • 1Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA.

Seminars in Reproductive Endocrinology
|June 14, 2000
PubMed
Summary
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Aging adrenal glands show declining adrenal androgens dehydroepiandrosterone (DHEA) and DHEAS, linked to zona reticularis loss. DHEA replacement in aging is reviewed for potential benefits in age-related diseases.

Area of Science:

  • Endocrinology
  • Aging Research
  • Adrenal Gland Physiology

Background:

  • The adrenal cortex undergoes significant age-related changes in structure and hormone production.
  • Adrenal androgens, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS), notably decrease with age.
  • This decline is associated with the loss of the zona reticularis, the adrenal cortex's inner layer.

Purpose of the Study:

  • To review age-associated alterations in adrenal cortex morphology and steroidogenesis.
  • To explore the clinical significance of these changes, particularly the decline in adrenal androgens.
  • To examine existing clinical data on dehydroepiandrosterone (DHEA) replacement therapy in aging individuals.

Main Methods:

  • Literature review of studies on adrenal cortex aging.

Related Experiment Videos

  • Analysis of age-related changes in aldosterone, cortisol, DHEA, and DHEAS levels.
  • Synthesis of clinical findings regarding DHEA supplementation in the elderly.

    • Main Results:

    • Aldosterone shows a subtle decline, while cortisol slightly increases with age.
    • A significant decrease in dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) is observed.
    • The zona reticularis is substantially diminished in aged adrenal glands.

    Conclusions:

    • Age-related decline in adrenal androgens and zona reticularis integrity is a key finding.
    • The clinical implications of these changes, including their potential role in age-related diseases, warrant further investigation.
    • The efficacy and safety of dehydroepiandrosterone (DHEA) replacement therapy in aging require continued clinical evaluation.